Take this by with or without food as directed by your doctor, usually every 12 hours. The dosage is based on your medical condition and response to treatment. Morphine sulfate is an opioid agonist. Morphine Sulfate Injection USP is available as a sterile, nonpyrogenic solution of morphine sulfate, free of antioxidants and preservatives in pre-filled syringes for intravenous and intramuscular administration. Each 1 mL pre-filled syringe contains 2 mg, 4 mg, 5 mg, 8 mg or 10 mg of Morphine Sulfate USP in 1 mL total volume. The safety of linezolid formulations was evaluated in 215 pediatric patients ranging in age from birth through 11 years, and in 248 pediatric patients aged 5 through 17 years 146 of these 248 were age 5 through 11 and 102 were age 12 to 17. These patients were enrolled in two Phase 3 comparator-controlled clinical trials and were treated for up to 28 days. protopic-ointment
They should inform their physician if they have a history of hypertension. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for Morphine Sulfate Injection and any potential adverse effects on the breastfed infant from Morphine Sulfate Injection or from the underlying maternal condition. Tramadol may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents. The dosage is based on your medical condition and response to treatment. Pain work best if they are used as the first occur. If you wait until the symptoms have worsened, the medication may not work as well.
Linezolidis indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below. Linezolid is not indicated for the treatment of Gram-negative infections. Administer the injection slowly. AUCs of linezolid during pregnancy and lactation, survival of pups was decreased on postnatal days 1 to 4. Male and female pups permitted to mature to reproductive age, when mated, showed an increase in preimplantation loss.
Inform your doctor if your condition persists or worsens. Avoid drinking fruit juices or taking vitamin C at the same time you take amphetamine. These can make your body absorb less of the medicine. Inactive Ingredients: gelatin capsules, hydroxypropyl methylcellulose, methacrylic acid copolymer, opadry beige, sugar spheres, talc, and triethyl citrate. Gelatin capsules contain edible inks, kosher gelatin, and titanium dioxide. Zyvox linezolid UK summary of product characteristics. Know the medicines that you or your child takes. Keep a list of your medicines with you to show your doctor and pharmacist.
After you apply this drug, your may become temporarily blurred. This drug may also make you dizzy or drowsy. not drive, use machinery, or do any activity that requires alertness or clear until you are sure you can perform such activities safely. Limit beverages. Avoid drinking alcohol while you are taking this medicine. Protect from light. It is recommended that the infusion bags be kept in the overwrap until ready to use. Protect infusion bags from freezing. The safety and efficacy of linezolid formulations given for longer than 28 days have not been evaluated in controlled clinical trials. Ask your doctor or pharmacist about other ways to decrease such as lying down for 1 to 2 hours with as little head movement as possible. Prescription should not depend solely on the presence of one or more of the behavioral characteristics. When these symptoms are associated with acute stress reactions, treatment with amphetamines is usually not indicated. What happens if I overdose? Absorption: Linezolid is extensively absorbed after oral dosing. Maximum plasma concentrations are reached approximately 1 to 2 hours after dosing, and the absolute bioavailability is approximately 100%. Therefore, linezolid may be given orally or intravenously without dose adjustment. Adderall XR may affect you or your child's ability to drive or do other dangerous activities. If you are using the liquid form, carefully measure your prescribed dose using a medication-measuring device or spoon. not use a household spoon because you may not get the correct dose. Read the Guide provided by your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Protein binding is low, about 36%, and muscle tissue binding is reported as 54%. They may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Injection 600 mg every 12 hours, and the other group received vancomycin 1 g every 12 hours intravenously. Both groups received concomitant aztreonam 1 to 2 g every 8 hours intravenously which could be continued if clinically indicated. There were 203 linezolid-treated and 193 vancomycin-treated patients enrolled in the study. One hundred twenty-two 60% linezolid-treated patients and 103 53% vancomycin-treated patients were clinically evaluable. The cure rates in clinically evaluable patients were 57% for linezolid-treated patients and 60% for vancomycin-treated patients. The cure rates in clinically evaluable patients with ventilator-associated pneumonia were 47% for linezolid-treated patients and 40% for vancomycin-treated patients. A modified intent-to-treat MITT analysis of 94 linezolid-treated patients and 83 vancomycin-treated patients included subjects who had a pathogen isolated before treatment. The cure rates in the MITT analysis were 57% in linezolid-treated patients and 46% in vancomycin-treated patients. Advise patients that Adderall XR is a federally controlled substance because it can be abused or lead to dependence. Initial Dose: 10 mg once a day orally upon awakening. Tachycardia, bradycardia, palpitation, faintness, syncope and orthostatic hypotension. The effects of Adderall XR on labor and delivery in humans is unknown. Some stimulants have caused sudden death in certain people. Even though most healthy people are not at risk for becoming infected or colonized with VRE, you can take steps to prevent getting a VRE infection. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated. Linezolid may also be used for purposes not listed in this medication guide. What is the most important information I should know about linezolid? Monitor patients for signs of urinary retention or reduced gastric motility when Morphine Sulfate Injection is used concomitantly with anticholinergic drugs. Specific etiology of this syndrome is unknown, and there is no single diagnostic test. Adequate diagnosis requires the use not only of medical but of special psychological, educational, and social resources. Learning may or may not be impaired. Included as part of the PRECAUTIONS section. Swallow Adderall XR capsules whole with water or other liquids. If you or your child cannot swallow the capsule, open it and sprinkle the medicine over a spoonful of applesauce. Swallow all of the applesauce and medicine mixture without chewing immediately. Follow with a drink of water or other liquid. Never chew or crush the capsule or the medicine inside the capsule. Maintenance Dose: The daily dosage may be increased in increments of 10 mg at weekly intervals, up to 60 mg per day in 2 to 3 divided doses. Give first dose on awakening; additional doses 1 or 2 at intervals of 4 to 6 hours. diltiazem-ointment
Table 6 should be observed. Tenth Edition. CLSI document M07-A10, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015 2. Clinical and Laboratory Standards Institute CLSI. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-fifth Informational Supplement. CLSI document M100-S25, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2015 3. Clinical and Laboratory Standards Institute CLSI. Gentamicin: The pharmacokinetics of linezolid or gentamicin are not altered when administered together. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if color is darker than pale yellow, if it is discolored in any other way or if it contains a precipitate. Adult patients with clinically and radiologically documented nosocomial pneumonia were enrolled in a randomized, multi-center, double-blind trial. Patients were treated for 7 to 21 days. All patients treated with opioids require careful monitoring for signs of abuse and addiction, because use of opioid analgesic products carries the risk of addiction even under appropriate medical use. Lactic acidosis has been reported with the use of linezolid. In reported cases, patients experienced repeated episodes of nausea and vomiting. Patients who develop recurrent nausea or vomiting, unexplained acidosis, or a low bicarbonate level while receiving linezolid should receive immediate medical evaluation. Linezolid is a reversible, nonselective inhibitor of monoamine oxidase. Therefore, linezolid has the potential for interaction with adrenergic and serotonergic agents. The opioid antagonists, naloxone or nalmefene, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to morphine overdose, administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to morphine overdose. Although the risk of addiction in any individual is unknown, it can occur in patients appropriately prescribed Morphine Sulfate Injection. Addiction can occur at recommended dosages and if the drug is misused or abused. If you are taking this under your doctor's direction, your doctor or may already be aware of any possible and may be monitoring you for them. not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first. The results from a population-based prospective cohort, including 70 women exposed to morphine during the first trimester of pregnancy and 448 women exposed to morphine at any time during pregnancy, indicate no increased risk for congenital malformations. However, these studies cannot definitely establish the absence of any risk because of methodological limitations, including small sample size and non-randomized study design. If you are in the hospital, remind doctors and nurses to wash their hands before they touch you. Read the Patient Information Leaflet if available from your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Dispense in a tight, light-resistant container as defined in the USP. buy reductil amsterdam reductil
Diarrhea is a common problem caused by antibiotics, which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. Keep all regular medical and laboratory appointments. Stimulants, including Adderall XR, used to treat ADHD are associated with peripheral vasculopathy, including Raynaud's phenomenon. Research shows that it can be cured around 30% to 50% of the time. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. The mode of therapeutic action in ADHD is not known. Amphetamines are thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space. Both groups received concomitant aztreonam 1 to 2 g every 8 hours intravenously which could be continued if clinically indicated. There were 203 linezolid-treated and 193 vancomycin-treated patients enrolled in the study. One hundred twenty-two 60% linezolid-treated patients and 103 53% vancomycin-treated patients were clinically evaluable. Doctors call this "drug-resistant" TB. If you have this form of the disease, you may need to take stronger medications for longer. Maximum Dose: Only in rare cases will it be necessary to exceed 40 mg per day. All steps must be done sequentially. Miguel Sanchez Garcia, MD, PhD, of the Hospital Clinico San Carlos and Universidad Complutense in Madrid, Spain, says in an email. price tricor 40mg tab
This Medication Guide summarizes the most important information about Adderall XR. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about Adderall XR that was written for healthcare professionals. Monitor patients closely for respiratory depression, especially within the first 24 to 72 hours of therapy and following doe increases. The pharmacokinetics of linezolid following a single intravenous dose were investigated in pediatric patients ranging in age from birth through 17 years including premature and full-term neonates in healthy adolescent subjects ranging in age from 12 through 17 years, and in pediatric patients ranging in age from 1 week through 12 years. The pharmacokinetic parameters of linezolid are summarized in Table 9 for the pediatric populations studied and healthy adult subjects after administration of single intravenous doses. Do not share personal items such as towels or razors. Dextromethorphan: The potential drug-drug interaction with dextromethorphan was studied in healthy volunteers. Subjects were administered dextromethorphan two 20-mg doses given 4 hours apart with or without linezolid. No serotonin syndrome effects confusion, delirium, restlessness, tremors, blushing, diaphoresis, hyperpyrexia have been observed in normal subjects receiving linezolid and dextromethorphan. Co-administration of Adderall XR and gastrointestinal or urinary alkalinizing agents should be avoided. Marked mydriasis rather than miosis may be seen due to hypoxia in overdose situations. bera.info uroxatral
It is not known whether this drug passes into milk. Consult your doctor before -feeding. Psychotic episodes at recommended doses, overstimulation, restlessness, irritability, euphoria, dyskinesia, dysphoria, depression, tremor, tics, aggression, anger, logorrhea, dermatillomania, paresthesia including formication and bruxism. Zyvox may be taken with or without food. Morphine may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression. Most important. A change in your diet, medicine, or dosage is likely to be necessary. Promptly consult your doctor or pharmacist. Injection is supplied in single-use, ready-to-use infusion bags. Parenteral drug products should be inspected visually for particulate matter prior to administration. Check for minute leaks by firmly squeezing the bag. Therefore, -feeding is not recommended while using this drug. Consult your doctor before breast-feeding. If any of these effects persist or worsen, notify your doctor or promptly. Prolonged use of Morphine Sulfate Injection during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. Store at room temperature between 68-77 degrees F 20-25 degrees C away from light and moisture. Brief storage between 59-86 degrees F 15-30 degrees C is permitted. not store in the bathroom. Keep all medicines away from children and pets. Patients should be counseled that antibacterial drugs including linezolid should only be used to treat bacterial infections. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. The ER products should not be used with other tramadol products and should not be taken more often than once a day. Therefore, do not use this medication more often or for longer than prescribed. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.
Nardil phenelzine sulfate US prescribing information. Amphetamine may be habit-forming. Never share amphetamine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law. Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use. Presentation of adrenal insufficiency may include non-specific symptoms and signs including nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. If adrenal insufficiency is suspected, confirm the diagnosis with diagnostic testing as soon as possible. If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. Wean the patient off of the opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers. Other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal insufficiency. The information available does not identify any particular opioids as being more likely to be associated with adrenal insufficiency. None of the above analyses were adjusted for the use of adjunctive therapies. If urgent use of an opioid is necessary, use test doses and frequent titration of small doses of other opioids such as oxycodone, hydrocodone, oxymorphone, hydrocodone, or buprenorphine to treat pain while closely monitoring blood pressure and signs and symptoms of CNS and respiratory depression. If you experience muscle twitching, tremors, shivering and stiffness, fever, heavy sweating, heart palpitations, restlessness, confusion, agitation, trouble with coordination, or severe diarrhea contact your doctor right away. Therefore, linezolid is not expected to affect the pharmacokinetics of other drugs metabolized by these major enzymes. Concurrent administration of linezolid does not substantially alter the pharmacokinetic characteristics of S-warfarin, which is extensively metabolized by CYP2C9. Drugs such as warfarin and phenytoin, which are CYP2C9 substrates, may be given with linezolid without changes in dosage regimen. Do not use if package has been damaged. Adult patients with clinically and radiologically documented nosocomial pneumonia were enrolled in a randomized, multi-center, double-blind trial. Patients were treated for 7 to 21 days. One group received Linezolid Injection 600 mg every 12 hours, and the other group received vancomycin 1 g every 12 hours intravenously. Both groups received concomitant aztreonam 1 to 2 g every 8 hours intravenously which could be continued if clinically indicated. There were 203 linezolid-treated and 193 vancomycin-treated patients enrolled in the study. One hundred twenty-two 60% linezolid-treated patients and 103 53% vancomycin-treated patients were clinically evaluable. The cure rates in clinically evaluable patients were 57% for linezolid-treated patients and 60% for vancomycin-treated patients. The cure rates in clinically evaluable patients with ventilator-associated pneumonia were 47% for linezolid-treated patients and 40% for vancomycin-treated patients. A modified intent-to-treat MITT analysis of 94 linezolid-treated patients and 83 vancomycin-treated patients included subjects who had a pathogen isolated before treatment. The cure rates in the MITT analysis were 57% in linezolid-treated patients and 46% in vancomycin-treated patients. Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. Initiate with lower doses and monitor patients for signs and symptoms of serotonin syndrome, particularly during Adderall XR initiation or dosage increase. Morphine Sulfate Injection exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Peripheral and optic neuropathies have been reported in patients treated with Linezolid Injection, primarily in those patients treated for longer than the maximum recommended duration of 28 days. In cases of optic neuropathy that progressed to loss of vision, patients were treated for extended periods beyond the maximum recommended duration. Visual blurring has been reported in some patients treated with Linezolid Injection for less than 28 days. Peripheral and optic neuropathy has also been reported in children. With the proper treatment, TB, for short is almost always curable. online drugstore depakote
People with dangerous strains, such as an extensively drug-resistant TB, are also quarantined. The goal is to prevent the spread of the disease. Tell your doctor about any mental problems you or your child have, or about a family history of suicide, bipolar illness, or depression. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet. If you use the extended-release tablet, the tablet shell may pass into your stools bowel movements. This is normal and does not mean that you are not receiving enough of the medicine. Adverse reactions reported in a 3-week clinical trial of children and a 4-week clinical trial in adolescents and adults, respectively, treated with Adderall XR or placebo are presented in the tables below. Morphine Sulfate Injection is available in the following strengths for intravenous IV and intramuscular IM administration. Pharmacokinetic information generated in pediatric patients with ventriculoperitoneal shunts showed variable cerebrospinal fluid CSF linezolid concentrations following single and multiple dosing of linezolid; therapeutic concentrations were not consistently achieved or maintained in the CSF. Therefore, the use of linezolid for the empiric treatment of pediatric patients with central nervous system infections is not recommended. The safety and efficacy of Linezolid Injection formulations given for longer than 28 days have not been evaluated in controlled clinical trials. Doctors should not all the blame, he says. Antibiotics are also used indiscriminately in the agriculture setting, he says. Administration of Morphine Sulfate Injection should be limited to use by those familiar with the management of respiratory depression. Morphine must be injected slowly; rapid intravenous administration may result in chest wall rigidity. Ask your doctor or pharmacist about using tramadol safely with other drugs. erythromycin mail order store europe
Large quantities of foods or beverages with high tyramine content should be avoided while taking linezolid. Foods high in tyramine content include those that may have undergone protein changes by aging, fermentation, pickling, or smoking to improve flavor, such as aged cheeses, fermented or air-dried meats, sauerkraut, soy sauce, tap beers, and red wines. The tyramine content of any protein-rich food may be increased if stored for long periods or improperly refrigerated. Read the Guide available from your before you start using and each time you get a refill. If you have any questions, consult your doctor or pharmacist. All patients were treated for a total of 10 to 28 days and could receive concomitant Gram-negative antibiotics if clinically indicated. In the intent-to-treat ITT population, there were 206 patients randomized to linezolid and 102 patients randomized to vancomycin. The cure rates for ITT, MITT, and clinically evaluable patients are presented in Table 18. After the study was completed, 13 additional patients ranging from 4 days through 16 years of age were enrolled in an open-label extension of the VRE arm of the study. Table 19 provides clinical cure rates by pathogen for microbiologically evaluable patients including microbiologically evaluable patients with vancomycin-resistant Enterococcus faecium from the extension of this study. To help you remember, your doctor may need to watch you take your medication. Patients should be counseled that antibacterial drugs including Zyvox should only be used to treat bacterial infections. Linezolid has no clinical activity against Gram-negative pathogens and is not indicated for the treatment of Gram-negative infections. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use tramadol only for the indication prescribed. Concerta is not approved for use by anyone younger than 6 years old. Do not use in series connections. TZD” on one side and “200” on the other side. Morphine Sulfate Injection may reduce respiratory drive, and the resultant CO 2 retention can further increase intracranial pressure. Depending on your risk factors, latent TB can re-activate and cause an active infection. Antibiotics: Aztreonam: The pharmacokinetics of linezolid or aztreonam are not altered when administered together. Gentamicin: The pharmacokinetics of linezolid or gentamicin are not altered when administered together. Injection may exhibit a yellow color that can intensify over time without adversely affecting potency. danazol best price uk
Tell your doctor if you or your child have any heart problems, heart defects, high blood pressure, or a family history of these problems. High tyramine level foods include aged cheeses cheddar, camembert, emmenthaler, brie, stilton blue, gruyere, gouda, brick, bleu, roquefort, boursault, parmesan, romano, provolone, liederdranz, colby, edam; aged, dried, fermented, salted, smoked, pickled and processed meats and fish includes bacon, summer sausage, liverwurst, hot dogs, corned beef, pepperoni, salami, bologna, ham, mortadella, pickled or dried herring; banana peel; beef and chicken liver stored, not fresh; bouillon cubes, commercial gravies; concentrated yeast extracts marmite; fava beans, Italian green beans, broad beans, fermented bean curd, homemade yeast-leavened bread; kim chee Korean fermented cabbage; miso, orange pulp; overripe or spoiled fruits; packaged soups, red wine, sauerkraut, sherry, snow pea pods, sourdough bread, soy sauce, soya bean, soya bean paste; tap beer and ale; vermouth. Take the missed dose as soon as you remember, but not late in the day or you could have trouble sleeping. Skip the missed dose if it is almost evening. Do not take extra medicine to make up the missed dose. Amphetamine is not approved for use by anyone younger than 6 years old. Discontinue treatment with Adderall XR and any concomitant serotonergic agents immediately if symptoms of serotonin syndrome occur, and initiate supportive symptomatic treatment. Concomitant use of Adderall XR with other serotonergic drugs or CYP2D6 inhibitors should be used only if the potential benefit justifies the potential risk. If clinically warranted, consider initiating Adderall XR with lower doses, monitoring patients for the emergence of serotonin syndrome during drug initiation or titration, and informing patients of the increased risk for serotonin syndrome. Keep track of the number of Concerta extended-release tablets used from each new bottle. Methylphenidate is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. The molecular weight is 758. chloroquine
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Alkaline urine pHs result in less ionization and reduced renal elimination, and acidic pHs and high flow rates result in increased renal elimination with clearances greater than glomerular filtration rates, indicating the involvement of active secretion. Urinary recovery of amphetamine has been reported to range from 1% to 75%, depending on urinary pH, with the remaining fraction of the dose hepatically metabolized. Consequently, both hepatic and renal dysfunction have the potential to inhibit the elimination of amphetamine and result in prolonged exposures. Clostridium difficileassociated diarrhea CDAD has been reported with use of nearly all antibacterial agents, including Linezolid Injection, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile. order aricept interaction
Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment. In vitro studies have demonstrated additivity or indifference between linezolid and vancomycin, gentamicin, rifampin, imipenem-cilastatin, aztreonam, ampicillin, or streptomycin. Sublimaze fentanyl citrate US prescribing information. Thrombocytopenia associated with the use of linezolid appears to be dependent on duration of therapy generally greater than 2 weeks of treatment. If you or your child takes too much Adderall XR or overdoses, call your doctor or poison control center right away, or get emergency treatment.
Fatal side effects can occur if you use tramadol with alcohol, or with other drugs that cause drowsiness or slow your breathing. Your doctor may need to adjust your diabetes medication during treatment with this drug. Adderall XR can be taken with or without food. Tell your doctor if your condition persists or worsens after 7-10 days.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Adderall XR for a condition for which it was not prescribed. Do not give Adderall XR to other people, even if they have the same condition. It may harm them and it is against the law. Always ask your doctor if antibiotics are the best treatment. And avoid pressuring your doctor into prescribing antibiotics when he or she thinks they won't help you get better. Antibiotic resistance, which has been called one of the three greatest threats to human health by the World Health Organization, occurs when bacteria wise up to the presence of an antibiotic and morph into superbugs that can survive and thrive in its presence.